A Structural Model of the GDP Dissociation Inhibitor Rab Membrane Extraction Mechanism

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

Rab proteins comprise a family of small GTPases that serve a regulatory role in membrane traffic. These proteins are in part cytosolic and in part associated with the membranes of specific exocytic and endocytic organelles. Smg p25A/rab3A GDI, a cytosolic protein which inhibits the dissociation of GDP from smg p25A/rab3A, Sec4p, and rab11, has also been found to prevent association of rab3A wit...

Rab-GDP dissociation inhibitor isoforms in Arabidopsis thaliana

Rab-GDP dissociation inhibitor protein (rab-GDI) plays an essential role in secretory pathways. To date, the question of multiplicity of GDI isoforms in higher plants remains open and dbEST search, PCR and Southern blot analysis have been used to assess the isoform composition of rab-GDI in Arabidopsis thaliana. A novel rab-GDI isoform, ,4rGDI2, was identified which shares 90% identity in amino...

Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor.

Mutations in the presenilin 1 ( PS-1 ) gene cause Alzheimer's disease (AD). These mutations alter the processing of the amyloid precursor protein (APP) by increasing the production of the fibrillogenic amyloid fragment, Abeta1-42/43. Since the secretase activities that process APP are localized in different intracellular compartments, it is likely that membrane transport is a key factor in the ...

Rab GDP dissociation inhibitor: putting rab GTPases in the right place.

a structural survey of the polish posters

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